MOTS-C

MOTS-c is a research peptide derived from mitochondria and composed of 16 amino acids (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg). Encoded within the mitochondrial 12S rRNA gene, it regulates cellular metabolism through AMPK activation and mitochondrial homeostasis in preclinical studies. MOTS-c is widely used in metabolic and aging research investigating mitochondrial signaling, stress adaptation, and energy regulation mechanisms.

For research use only. Not for human consumption.

References:
Lee C et al., Cell Metab, 2015;21(3):443–454
Kim KH et al., Nat Commun, 2018;9(1):4774
Lee C et al., Cell Metab, 2016;23(2):303–309