Tirzepatide

Tirzepatide is a synthetic linear peptide acting as a dual agonist for both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. Research indicates that its unique imbalanced agonism—favoring GIP receptor binding—synergistically enhances insulin secretion and sensitivity while modulating glucagon levels more effectively than selective GLP-1 receptor agonists. It serves as a critical model for investigating metabolic disorders, specifically in the context of glycemic control, lipolysis, and significant body weight regulation.

For research use only. Not for human consumption.

References: Coskun T et al., Mol Metab, 2018 18:3–14 Frias JP et al., N Engl J Med, 2021 385(6):503–515 Rosenstock J et al., Lancet, 2021 398(10295):143–155